Hao-Li Liu   (劉浩澧)

 

Professor, Director

Department of Electrical Engineering 

Chang Gung University, Taiwan 

Hao-Li Liu.jpg

 

 

Phone886-3-2118800-3778

E-mail haoliliu@mail.cgu.edu.tw

Research fieldBiomedical electronics, therapeutic ultrasound, medical physics, medical imaging

Personal link Google Scholar  Research Activities  Lab   

 

Teaching :  Lecture material

 

Degree:  Ph.D. Institute of Electrical Engineering, National Taiwan University, Taiwan

 

 

 

 

Biography 

 

Hao-Li Liu received the Ph.D. degrees in Electrical Engineering in 2003 from the National Taiwan University, Taipei, Taiwan. In 2004-2005, He was the research fellow of the Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. He is currently the Professor and the Director of Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, and also the Adjunct Assistant Researcher of Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan. Dr. Liu is currently continuing research in ultrasound thermal therapy and its treatment planning/ simulation, ultrasound-induced blood brain barrier (BBB) disruption for brain drug delivery, ultrasound phased array design. Dr. Liu has published over 80 SCI papers (more than 10 are high ranked papers with the impact factors > 10), 19 USA/Taiwan patents in areas of biomedical use of therapeutic ultrasound. He received the Distinguished Tech-Coop Award (2011,2014) and the Distinguished Research Award (2010) from Chang-Gung University, respectively. Also in 2011, He received the Wu Ta-You Memorial Award from the National Science Council in Taiwan. In 2013, he received the Frederic Lizzi Award from the International Society for Therapeutic Ultrasound (ISTU) and also the Excellent Young Electrical Engineer Award from the Chinese Institute of Electrical Engineering to acknowledge his significant research contributions to therapeutic ultrasound. Dr. Liu is a member of IEEE and International Society of Therapeutic Ultrasound (ISTU).

 

Academic appointment:

l  2013 – present, Adjunct Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

l  2012 – present, Director, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

l  2011 – present, Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

l  2008 – 2011, Associate Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

l  2006 – 2012, Adjunct Assistant Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

l  2005 – 2008, Assistant Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan

l  2004 –2005, Research Fellow, Focused Ultrasound Laboratory (principal investigator: Prof. Kullervo Hynynen), Department of Radiology, Brigham & Women’s Hospital, Harvard Medical School, MA, USA

 

Award:

·      2014, Taiwan Healthcare and Agricultural Biotech Industries Innovation and Excellence Awards, The Epoch Foundation(台灣生醫暨生農選秀大賽/潛力新秀獎首獎)

·      2014, Distinguished Tech-Coop Award (長庚大學優良教師技合獎), Chang-Gung University.

·      2013, Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) from The Chinese Institute of Electrical Engineering, ROC (中國電機工程學會).

·      2013, Frederick Lizzi Early Career Award, International Society for Therapeutic Ultrasound (ISTU).

·      2011, Distinguished Tech-Coop Award (長庚大學優良教師技合獎), Chang-Gung University

·      2011, Wu Ta-You Memorial Award (吳大猷先生紀念獎), National Science Council, Taiwan, 2011.

·      2010, Distinguished Research Award (長庚大學優良教師研究獎), Chang-Gung University.

 

 

License

·  Professional Electrical Engineer, Taiwan (中華民國電機技師 (八十八年電機技師高考及格))

·  Medical Engineer, Taiwan (中華民國醫學工程師 )

 

 

 

 

 

Publication

 

 (A)SCI Journal

2014:

1.        HY Huang**, HL Liu**, PH Hsu, CS Chiang, CH Tsai, HS Chi, SY Chen, and YY Chen*, “Multitheragnostic Nanobubble System to Induce Brain-Blood Barrier Disruption with Magnetically Guided Focused Ultrasound,” Advanced Materials, Accepted, 2014 (**Equal Contribution; IF=15.409, 7/148 in “Chemistry, Multidisciplinary”)

2.        MT Tsai, FY Chang, CK Lee, CS Gong, YX Lin, JD Lee, CH Yang, HL Liu*, “Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography,” Biomedical Optics Express. Vol. 5, No. 7, pp. 2009-22, 2014. (*Corresponding author; IF = 3.497, 7/84 in “Optics”).

3.        CH Fan, WH Lin, CY Ting, WY Chai, TC Yen, HL Liu* and CK Yeh, “Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Theranostics, Vol. 4, No. 10, pp. 1014-1025, 2014 (*Corresponding author; IF = 7.827, 9/122 in “Medicine, Research and Experimental”).

4.        WY Chai, PC Chu, MY Tsai, YC Lin, JJ Wang, KC Wei, YY Wai and HL Liu*, “Magnetic-Resonance Imaging for Kinetic Analysis of Permeability Changes during Focused Ultrasound-Induced Blood-Brain Barrier Opening and Brain Drug Delivery,” Journal of Controlled Release, Vol. 192, pp.1-9, 2014 (SCI IF = 7.261, 11/254 in “Pharmacology & Pharmacy”)

5.        AH Liao, HY Chou, YL Hsieh, SC Hsu, KC Wei, and HL Liu*, Enhanced Therapeutic Epidermal growth factor receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment,” Journal of Medical and Biomedical Engineering, Accepted, 2014 (SCI IF = 0.904, 60/79 in “Engineering, Biomedical”).

6.        J Xia, Q Li,PY Chen, Z Zhou,CY Wang, HL Liu, J Teng, and PH Tsui, "Considering Angle Selection When Using Ultrasound Electrode Displacement Elastography to Evaluate Radiofrequency Ablation of Tissues," BioMed Research International, Volume 2014, ID 764320, 2014 (SCI IF = 2.88, 65/158 in "Biotech. and App. Microbiology")

7.        HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, YJ Lu, KC Wei, CCM Ma, “Gadolinium-functionalized nanographene oxide for combined drug and microRNA delivery and magnetic resonance imaging,” Biomaterials, Vol. 35, pp.6534-6542, 2014 (IF = 8.312, 2/77 in “Engineering, Biomedical”).

8.        CH Fan**, HL Liu**, CY Ting, YH Lee, CY Huang, YJ Ma, KC Wei, TC Yen and CK Yeh, “Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery,” PLoS ONE, Vol.9, No. 5, e96327, 2014 (**Equal contribution, SCI IF = 3.534, 8/55 in "Multidisciplinary Sciences")

9.        X Geng, Z Zhou, Q Li, S Wu, CY Wang, HL Liu, CC Chuang, and PH Tsui, “Comparison of ultraosund temperature imaging with infrared thermometry during radio frequency ablation,” Japanese Journal of Applied Physics, Vol. 53, No. 4, pp. 047001, 2014 (IF = 1.067, 82/128 in Phycis, Applied)

10.    HL Liu*, CK Jan, PC Chu, JC Hong, PY Lee, JD Hsu, CC Lin, CY Huang, PY Chen, and KC Wei*, “Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Opening and Brain Drug Delivery,” IEEE Transactions on Biomedical Engineering, Vol.61, No. 4, pp.1350-1360, 2014 (IF=2.233, 29/77 in “Engineering, Biomedical”).

11.    HL Liu, CH Fan, CY Ting, and CK Yeh, "Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors" Theranostics, Vol. 4, No. 4, pp.432-444, 2014 (IF = 7.827, 9/122 in “Medicine, Research and Experimental”).

12.    HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, PW Hsu, YJ Lu, KC Wei, CCM Ma, “Gadolinium-functionalized nanographene oxide as a nanocarrier for combined drug and microRNA delivery and magnetic resonance imaging,” Nano Research, accepted, 2014 (IF = 7.392, 17/241 in Materials Science, Multidisciplinary).

2013:

13.    JJ Xia, Q Li, HL Liu, WS Chen and PH Tsui, "An Approach for the Visualization of Temperature Distribution in Tissues According to Changes in Ultrasonic Backscattered Energy," Computational and Mathematical Methods in Medicine, Volume 2013, Article ID 682827 (IF = 0.791).

14.    YW Huang, SH Hu, SY Hung, CS Chiang, HL Liu, TL Chiou, HY Lai, YY Chen, "SPIO Nanoparticle-Stabilized Nanobubbles with MR/US Dual-Modality Imaging and HIFU-triggered Release Drug for in-vivo Therapy," Journal of Controlled Release, Vol. 172, pp.118-127, 2013 (IF = 7.633 in "Chemistry, Multidisciplinary).

15.    HW Yang, YJ Lu, KJ Lin, SC Hsu, CY Huang, SH She, HL Liu, MC Xiao, SP Wey, PY Chen, TC Yen, KC Wei, CCM Ma, "EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy, " Biomaterials, Vol. 34, No. 29, pp. 7204-7214, 2013 (IF = 7.404 in "Engineering, Biomedical").

16.    MT Tsai, CK Lee, KM Lin, YX Lin, TH Lin, TC Chang and HL Liu*, "Quantitative Observation Evaluation of Focused Ultrasound Induced Vascular Leakage and Deformation after Focused Ultrasound Treatment Exposure via by using Fluorescein Angiography and Optical Coherence Tomography," Journal of Biomedical Optics, Vol.18, No. 10, pp.101307, 2013 (IF=2.881, 8/79 in “Optics”).

17.    CY Wang, TS Yeh, XN Geng, HL Liu, and PH Tsui, "Monitoring Radiofrequency Ablation with Ultrasound Nakagami Imaging," Medical Physics, Vol.40, No.7, pp.072901, 2013. (IF=3.012, 25/121 in “Radiology”). 

18.    H.W. Yang, M.Y. Hua, T.L. Hwang, K.J. Lin, C.Y. Huang, R.Y. Tsai, C.C.M. Ma, P.H. Hsu, S.P. Wey, P.W. Hsu, P.Y. Chen, Y.C. Huang, Y.J. Lu, T.C. Yen, L.Y. Feng, C.W. Lin, H.L. Liu*, K.C. Wei*. Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide. Advanced Materials, Vol. 25, No. 26, pp.3605-3611, 2013. (*Corresponding author; IF=15.409, 7/148 in “Chemistry, Multidisciplinary”).

19.    HW Yang, HL Liu**, ML Li, IW Hsi, CT Fan, CY Huang, YJ Lu, MY Hua, HY Chou, JW Liaw, CCM Ma and KC Wei, "Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy," Biomaterials, Vol. 34, pp.5651-5660, 2013. (**共同第一作者; IF = 8.312, 2/77 in “Engineering, Biomedical”).

20.    PC Chu, WY Chai, HY Hsieh, JJ Wang, SP Wey, CY Huang, KC Wei and HL Liu*, "Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors," BioMed Research International, Vol. 2013, pp. 627496, 2013 (*通訊作者; SCI IF = 2.88, 65/158 in "Biotech. and App. Microbiology").

21.    KC Wei, PC Chu, HYJ Wang, CY Huang, PY Chen, HC Tsai, YJ Lu, IC Tseng, PY Lee, TC Yen, and HL Liu*, "Focused Ultrasound-induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study, " PLoS ONE, Vol. 8, No. 3, pp. e58995, 2013 (*通訊作者; SCI IF = 3.534, 8/55 in "Multidisciplinary Sciences")

22.    C-H Fan, C-Y Ting, H-J Lin, C-H Wang, H-L Liu*, T-C Yen, C-K Yeh*, "SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery," Biomaterials, Vol. 34, pp. 3706-3715, 2013 (*共同通訊作者; IF = 8.312, 2/77 in “Engineering, Biomedical”)

23.    P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, "Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, " PLoS ONE, Vol. 8, No. 2, pp. e57682, 2013 (*通訊作者; SCI IF = 3.534, 8/55 in " Multidisciplinary Sciences ")

24.    K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, "A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery", ACS Nano, Vol. 7, No. 1, pp. 438-446, 2013 (IF=12.033, 9/148 in “Chemistry, Multidisciplinary””).

25.    C-H Fan, C-Y Ting, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh, "Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment, " Biomaterials, Vol. 34, pp. 2142-2155, 2013 (*共同通訊作者; IF = 8.312, 2/77 in “Engineering, Biomedical”).

26.    K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, “Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,” American Journal of Neuroradiology, Vol. 34, No. 1, pp. 115-120, 2013. (IF=3.675, 18/121 in “Radiology”)

2012:

27.    H-L Liu, H-Y Hsieh, L-A Lu, C-W Kang, M-F Wu and C-Y Lin, "Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response,", Journal of Translational Medicine, Vol. 10: 221, 2012 (IF = 3.474, 32/112 in "Medicine, Res. & Exp.")

28.    H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, pp. 1–11, 2012 (IF = 3.13, 16/66 in "Nanoscience & Nanotechnology").

29.    H-W Yang, M-Y Hua, H-L Liu, C-Y Huang, K-C Wei, Potential of magnetic nanoparticles for targeted drug delivery. Nanotechnology, Science and Applications, Vol. 5, pp. 73-86, 2012 (SCI).

30.    A-H Liao, Y-K Li, W-J Lee, M-F Wu, H-L Liu, and M-L Kuo, “Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 11, pp. 1938–1948, 2012 (IF=2.099, 5/29 in “Acoustics”).

31.    P-H Liao, H-H Yang, P-T Chou, M-H Wang, P-C Ju, H-L Liu, and L-K Chen, "Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats," Journal of Biomedical Sciences, Vol. 19: 61, 2012 (IF = 1.98)

32.    Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, “Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,” International Journal of Nanomedicine, Vol. 7, pp. 1–11, 2012 (IF = 3.13, 16/66 in "Nanoscience & Nanotechnology")

33.    C-J Ke, Y-J Lin, Y-C Hua, W-L Chiang, K-J Chen, W-C Yang, H-L Liu, C-C Fu, H-W Sung, “Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres,” Biomaterials, Vol. 33, No. 20, pp. 5156-5165, 2012. (IF = 8.312, 2/77 in “Engineering, Biomedical”).

34.    A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, “Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging,” Physics in Medicine and Biology, Vol. 57, pp.2787-2802, 2012 (**共同第一作者; IF = 2.922, 16/77 in “Engineering, Biomedical”)

35.    P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, "Ultrasound temperature estimation based on probability variation of backscatter data", Medical Physics, Vol. 39, No. 5, pp. 2369-2385, 2012 (IF=3.012, 25/121 in “Radiology”).  

36.    P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, "Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model", Journal of Biomedical Optics, Vol. 17, No. 6, pp. 061222, 2012 (**共同第一作者; IF=3.157, 7/77 in “Optics”).

37.    C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, “Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 8, pp. 1372–1382, 2012 (IF=2.099, 5/29 in “Acoustics”).

38.    P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen, “Using ultrasound CBE imaging without echo shift compensation for temperature estimation,” Ultrasonics, Vol. 52, No. 7, pp. 925-935, 2012. (IF=1.838, 5/30 in “Acoustics”)

39.    H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, S-T Pang, P-H Hsu, H-J Tang, T-C Yen, C-K Chuang, “An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,” Biomaterials, Vol. 33, pp. 3919-3930, 2012. (**共同第一作者; IF = 8.312, 2/77 in “Engineering, Biomedical”).

40.    H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang,H-C Chuang, K-J Yu, and S-T Pang, “Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy”, ACS Nano, Vol.6, No. 2, pp1795-1805, 2012 (**共同第一作者; IF=12.033, 9/148 in “Chemistry, Multidisciplinary””).

41.    Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, “Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,” Magnetic Resonance in Medicine, Vol. 68, No. 5, pp. 1439-1449, 2012 (IF=2.964, 26/116 in "Radiology")

42.    H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, “Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,” Neurosurgical Focus, Vol. 32, No. 1, E4, 2012 (IF = 2.487, 41/198 in “Surgery”). 

43.    C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*, “Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,” Biomaterials, Vol. 33, pp. 704-712, 2012 (*Co-corresponding author, IF = 8.312, 2/77 in “Engineering, Biomedical”).

2011:

44.    M-T Tsai, T-D Chi, H-L Liu, F-Y Chang, C-H Yang, C-K Lee, and C-C Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express, Vol. 4, pp.097001-3, 2011 (IF =3.013, 21/125 in “Physics, Applied”).

45.    W-S Chen, H-L Liu, Y.S. Tung, J.C. Wang, Y.H. Ding, C.K. Jan, “Reducing lesion aberration by dual-frequency focused ultrasound ablations,” International Journal of Hyperthermia, Vol. 27, No. 7, pp. 637-647, 2011 (IF=2.591, 37/116 in “Radiology”).

46.    C-J Ke, T-Y Su, H-Chen, H-L Liu, W-L Chiang, P-C Chu, Y Xia, H-W Sung, “Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments,” Angewandte Chemie International Edition, Vol. 50, No. 35, pp. 8086 – 8089, 2011 (IF = 13.734, 7/152 in “Chemistry, Multidisciplinary”)

47.    M-Y Hua**, H-W Yang**, H-L Liu**, R-Y Tsai, S-T Pang, K-L Chuang, Y-S Chang, T-L Hwang, Y-H Chang, H-C Chuang, C-K Chuang, “Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy,” Biomaterials, Vol. 32, pp. 8999-9910, 2011 (**共同第一作者, IF = 8.312, 2/77 in “Engineering, Biomedical”).

48.    J-J Wang , W-Y Lin, C-S Lu, Y-H Weng, S-H Ng , C-H Wang , H-L Liu, R-H Hsieh , Y-L Wan, and Y-Y Wai, “Parkinson Disease_Diagnostic Utility of Diffusion Kurtosis Imaging,” Radiology, Vol. 261, No. 1, pp. 210-217 (IF=6.214, 4/121 in“Radiology”).

49.    H-L Liu, P-Y Chen, H-W Yang, J-S Wu, I-C Tseng, Y-J Ma, C-Y Huang, H-C Tsai,  S-M Chen, Y-J Lu, C-Y Huang, M-Y Hua, Y-H Ma, T-C Yen and K-C Wei, “In Vivo MR Quantification of Superparamagnetic Iron Oxide Nanoparticle Leakage During Low-frequency-ultrasound–induced Blood–Brain Barrier Opening In Swine,” Journal of Magnetic Resonance Imaging, Vol. 34, No. 12, pp. 1313-1324, 2011 (IF=2.788, 29/121 in “Radiology”).

50.    H-W Yang**, M-Y Hua**, H-L Liu**, C-Y Huang, R-Y Tsai, Y-J Lu, J-Y Chen, H-J Tang, H-Y Hsien, Y-S Chang, T-C Yen, P-Y Chen and K-C Wei, “Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas,” Biomaterials, Vol. 32, pp. 6523-6532, 2011 (**共同第一作者, IF = 8.312, 2/77 in “Engineering, Biomedical”).

51.    W-S Chen, C-C Shen, C-T Ko, C-H Cheng, H-L Liu, M-C Ho, C-N Chen, C-K Yeh, “Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation,” IEEE Trans. Ultrason. Ferroelectrics Freq. Contr., Vol. 58, No. 4, pp. 766-775, 2011 (IF = 1.822, 7/31 in “Acoustics”)

52.    H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai, “An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,” Physics in Medicine and Biology, Vol. 56, pp. 169-186, 2011. (IF = 2.922, 16/77 in “Engineering, Biomedical”)

53.    M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas, Biomaterials, Vol. 32, pp. 512-523, 2011 (**共同第一作者, IF = 8.312, 2/77 in “Engineering, Biomedical”).

2010:

54.    H-L Liu, S-M Huang, and M-L Li, “High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,” Medical Physics, Vol. 37, No. 11, pp. 5921-5928, 2010 (IF=3.012, 25/121 in “Radiology”).

55.    H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010 (IF=9.809, 4/55 in “Multidisciplinary sciences”).

56.    K-C Ju and H-L Liu, “Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,” Journal of Ultrasound in Medicine, Vol. 29, pp.1607–1615, 2010 (IF=1.402, 13/31 in “Acoustics”).

57.    P-Y Chen**, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, “Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,” Neuro-oncology, Vol. 12, No. 10, pp.1050-1060, 2010 (**共同第一作者, IF=5.286, 30/202 in “Clinical Neurology”).

58.    H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang,  T-C Yen and K-C Wei, “Blood–Brain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,” Radiology, Vol. 255, No. 2, pp. 415-425, 2010 (IF=6.214, 4/121 in“Radiology”)

59.    H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, “Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,” Medical Physics, Vol. 37, No. 2, pp. 848-860, 2010 (IF=3.012, 25/121 in “Radiology”).

60.    H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, “Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,” Ultrasound in Medicine and Biology, Vol. 36, No. 2, pp. 325-335, 2010 (IF=2.099, 5/29 in “Acoustics”).

61.    Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, “Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,” American Journal of Neuroradiology, Vol. 31, pp. 269-274, 2010. (IF=3.675, 18/121 in “Radiology”)

62.    H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, “In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,” Journal of Cerebral Blood Flow & Metabolism, Vol. 30, pp. 168-177, 2010 (IF=5.339, 39/251 in “Neuroscience”).

2009:

63.    J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, “Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,” Journal of Neural Transmission, Vol. 116, pp. 1087 – 1092, 2009 (IF=2.73, 125/243 in “Neuroscience”).

64.    H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, "Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy," Ultrasound in Medicine and Biology, Vol. 35, No. 10, pp. 1647-1661, 2009 (IF=2.099, 5/29 in“Acoustics”).

65.    K-J Lin**, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, “Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,” Nuclear Medicine and Biology, Vol. 36, No. 7, pp. 853-867, 2009 (**共同第一作者, IF=2.408, 37/121 in “Radiology”).

66.    H-L Liu and C-M Hsieh, "Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation," Ultrasononics Sonochemistry, Vol. 16, No. 3, pp. 431-438, 2009 (IF=3.816, 3/29 in “Acoustics”).

67.    H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, "Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage," Journal of Magnetic Resonance Imaging, Vol. 29, No. 1, pp. 31-38, 2009 (IF=2.788, 29/121 in “Radiology”).

68.    H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, “Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption” IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, pp. 2407-2416., 2008 (IF=2.233, 29/77 in “Engineering, Biomedical”).

69.    J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,” Magnetic Resonance in Medicine, Vol. 59, No. 4, pp.764-770, 2008 (IF=3.267, 22/120 in “Radiology”).

70.    H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, “Hemorrhage Detection during Focused-Ultrasound Induced Blood–Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,” Ultrasound in Medicine & Biology, Vol. 34, No. 4, pp. 598-606, 2008 (IF=2.099, 5/29 in “Acoustics”).

71.    T-C Shih, H-L Liu, K-C Ju, C-S Huang, P-Y Chen, H-W Huang, Y-J Ho, “The feasibility of heating on tumor periphery by using high intensity focused ultrasound thermal surgery,” Int. Comm. Heat Mass Trans., Vol. 35, pp. 439-445, 2008 (IF=2.315, 8/54 in “Thermodynamics”).

72.    H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, “Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,” Medical Physics, Vol. 34, No. 9, pp. 3436-3448, 2007 (IF=3.012, 25/121 in “Radiology”).

73.    H-L Liu , T-C Shih , W-S Chen and K-C Ju,“A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,” Medical Physics, Vol. 34, No. 7, pp. 2957-2967, 2007 (IF=3.012, 25/121 in “Radiology”).

74.    H-L Liu, W-L Lin, and Y-Y Chen , “A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,” International Journal of Hyperthermia, Vol. 23, No. 1, pp. 69 – 82, 2007 (IF=2.591, 37/116 in “Radiology”).

75.    H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, "Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,” Ultrasound in Medicine & Biology, Vol. 32, No. 9, pp. 1411 – 1421, 2006 (IF=2.099, 5/29 in “Acoustics”).

76.    Y-S Tung, H-L Liu, C-C Wu, K-C Ju, W-S Chen, and W-L Lin, “Contrast-agent enhanced ultrasound thermal ablation,” Ultrasound in Medicine & Biology, Vol. 32, No. 7, pp. 1103 – 1110, 2006 (IF=2.099, 5/29 in “Acoustics”).

77.    W-S Chen, C-C Wu, S-Y Fang, H-L Liu* (Corresponding author), “Differences in the lesion formation process between focused ultrasound and microwave ablations,” Medical Physics, Vol. 33, No. 5, pp. 1346-1351, 2006 (IF=3.012, 25/121 in “Radiology”).

78.    H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, "Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,” Ultrasound in Medicine & Biology, Vol. 32, No. 5, pp. 759-767, 2006 (SCI IF:2.021, 4/31 in“Acoustics”).

79.    T-C Shih, H-L Liu, and Allen T-L Horng, “Cooling effect of thermally significant blood vessels in perfused tumor tissue during thermal therapy,” Int. Comm. Heat Mass Trans., Vol. 33, pp. 135-141, 2006 (IF=2.315, 8/54 in “Thermodynamics”).

80.    W-S Chen, P-M Ma, H-L Liu, C-K Yeh, M-S Chen, and C-W Chang, "A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers," J. Acoust. Soc. Am., Vol. 117, No. 6, pp.3740-3749, 2005 (IF=1.646, 9/31 in “Acoustics”).

81.    H-L Liu, Nathan McDannold, and K. Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Medical Physics, Vol. 32, pp.1270-1280, 2005 (IF=3.012, 25/121 in “Radiology”).

82.    H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “A Pilot Point Temperature Regulation for Thermal Dose Control during Ultrasound Thermal Therapy,” Medical & Biological Engineering & Computing, Vol. 42, pp. 178-188, 2004 (IF=1.791, 33/79 in “Engineering, Biomedical”).

83.    H-L Liu, Y-Y Chen, J-Y Yen, W-L Lin, “Thermal lesion formation and determination in external ultrasound thermal therapy,” Biomedical Engineering – Applications, Basis, and Communications, Vol. 15, No. 3, pp. 124-132, 2003 (EI ).

84.    H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “Treatment time reduction for large thermal lesions by using a multiple 1-d ultrasound phased array system,” Physics in Medicine and Biology, Vol. 48, pp.1173-1190, 2003 (IF=2.701, 19/79 in “Engineering, Biomedical”).

85.    W-L Lin, T-C Liang, J-Y Yen, H-L Liu and Y-Y Chen, “Optimization of power deposition and a heating strategy for ultrasound thermal therapy,” Medical Physics, Vol. 28, No. 10, pp. 2172-2181, 2001 (IF=3.012, 25/121 in “Radiology”).

86.    Y-Y Chen, W-L Lin, H-L Liu, J-Y Yen and M-J Shieh, “Self-tuning fuzzy logic control for ultrasound hyperthermia with reference temperature based on objective functions,” Medical Physics, Vol. 26, No. 5, pp. 825-833, 1999 (IF=3.012, 25/121 in “Radiology”).

 

 

 (B) Patents

1.        H-L Liu, S-F Chen, and H Chang, "Multiple-Frequency Ultrasonic Phased Array Driving System," U. S. Patent No. 8485974, July 16, 2013.

2.        H-L Liu, C-C Kung, T-C Chang, “Schlieren type ultrasonic wave observer system,” U. S. Patent, U.S. Patent No. 8,462,326, June 11, 2013.

3.        H-L Liu, W-L Lin, and H Chang, “Medical Treatment using an Ultrasound Phased Array,” U. S. Patent No. 8,287471, Oct 16, 2012.

4.        H-L Liu, C-H Kuo, and H-W Chen, Biomedical Used Multiple-Channel Hemispherical Focused Ultrasound Phased Array Apparatus, U. S. Patent No. 8,226,538, July 24, 2012.

5.        H-L Liu, I-Y Lu and S-M Huang, "Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound (HIFU) therapy system," U. S. Patent No. 8,226,559, July 24, 2012.

6.        H-L Liu, W-S Chen, and C-K Jan, “Precision Method and Apparatus for Controlling the Shape Memory Alloy,” U.S. Patent US8046994, Nov. 01, 2011.

7.        W-S Chen, H-L Liu, Y-T Huang, C-C Ma, W-B Tsai, W-P Shih, C-A Dai, “Artificial sphincter system,” US Patent No. 795389, June 7, 2011, 2011.

8.        H-L Liu and Chao-Ming Hsieh, “Multiple frequency driven ultrasound device,” US Patent No. 7,530,272, May. 12, 2009.

9.        劉浩澧、林明熙,一種具有超音波溫度影像及彈性影像之高能聚焦式超音波裝置及其使用方法,中華民國(發明), 已核准, 2014.

10.    劉浩澧、陳聖夫、張恕,複頻超音波相位陣列驅動系統, 中華民國(發明), 專利號I426245, Feb. 11, 2014.

11.    劉浩澧、龔崇誠、張庭嘉,一種光學式超音波觀測裝置及其延遲同步控制的方法,中華民國(發明), 專利號I409452, Sept. 21, 2013.

12.    劉浩澧、盧奕曄、黃聖閔, 非侵入式超音波即時溫度量測裝置, 中華民國(發明), 已核准, 2013.

13.    劉浩澧、黃文正, 非侵入式低頻超音波腦部治療裝置, 中華民國(發明), 申請號, 專利號I382860, Jan. 21, 2013.

14.    劉浩澧、林文澧、張恕, “一種以超音波相位陣列達到穿透肋骨治療之系統及方法, 中華民國(發明),” 專利號I377076, Nov. 21, 2012.

15.    劉浩澧、陳文翔、詹程凱,"一種形狀記憶合金的控制器裝置和控制方法,” 中華民國(發明), 專利號I367410, July 1, 2012.

16.    陳文翔、劉浩澧、黃彥棟、馬劍清、蔡偉博、施文彬、戴子安,人工括約肌系統,” 中華民國(發明), 專利號I351271, Nov. 11, 2011.

17.    劉浩澧、謝兆鳴, “多頻驅動單一換能器之超音波系統及訊號產生裝置”, 中華民國(發明), 專利號I323196, April 11, 2010.

18.    劉浩澧、郭鎮豪、陳恆文,生物醫療用半圓頭罩式超音波相位陣列裝置,” 中華民國(發明), 專利號I337087, Feb. 11, 2011.